Reclassification of missense variant pathogenicity using ClinGen recommendations for recalibrated PP3/BP4 in silico predictor score thresholds

To estimate the effect of ClinGen-calibrated variant effect predictor (VEP) score thresholds on clinically-reported missense variants of uncertain significance (VUS) reclassification using 2015 American College of Medical Genetics/Association for Molecular Pathology variant classification guidelines.