Ethical and social implications of implementing polygenic embryo screening into clinical care: A scoping review

Polygenic embryo screening (PES), or preimplantation genetic testing for polygenic conditions/traits (PGT-P), is an emerging application of polygenic risk scores within in-vitro fertilization (IVF). Commercially marketed to prospective parents, with limited professional guidelines, PES raises ethical and social concerns. To date, no scoping review has synthesized the ethical landscape of PES, which this study addresses by mapping ethical and sociocultural issues across academic literature. Following PRISMA guidelines, in September 2024, we searched PubMed, Web of Science, and PhilPapers, yielding 399 papers.